Genetic Testing and Diagnosis

Preimplantation genetic testing for aneuploidy (PGT-A), also known as preimplantation genetic screening (PGS), examines the embryo’s chromosomes in order to improve the likelihood of IVF success. An embryo — even a high quality one — with chromosomal issues will not develop into a healthy, normal baby. Chromosomal issues are the most common reason pregnancies fail, whether conceived naturally or through IVF.

PGT-A screens embryos for chromosomal issues so that the embryos we transfer give you the highest chance of successfully achieving pregnancy.

Preimplantation genetic testing for monogenic defects (PGT-M), also known as preimplantation genetic diagnosis (PGD), studies the embryo for a known inherited disease in your family, such as cystic fibrosis, thalassemia or sickle cell anemia.

Who should consider PGT-A or PGT-M?

  • Anyone with a family history of genetic diseases or disorders
  • Anyone with a chromosomal disorder
  • Women age 35 and over
  • Women who have experienced recurrent pregnancy loss or more than one failed fertility treatment

What are the benefits of PGT-A and PGT-M?

Some couples are hesitant to have biological children because one or both partners have a family history of genetic or chromosomal disorders. While PGT-M can’t entirely eliminate this risk of passing on a genetic or chromosomal disorder, it can drastically diminish it and make the difference in a couple’s decision to have children.

By screening out potential chromosomal problems early with PGT-A, we can maximize the potential for implantation and healthy development.

Are there concerns or risks related to PGT-A or PGT-M?

While very good at detecting genetic abnormalities, patients should know that PGT-A and PGT-M are not able to identify 100 percent of potential issues and do not replace the need for prenatal testing later during pregnancy.

For more information about PGT-A or PGT-M, please speak with your physician or contact a Midwest Fertility office.

Some individuals have ethical concerns with genetic testing and diagnosis. Each person or couple must form their own opinions and make the choices best for them. We are happy to discuss any concerns with you.